The SC-35 Splicing Factor Interacts with RNA Pol II and A-Type Lamin Depletion Weakens This Interaction
نویسندگان
چکیده
منابع مشابه
Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription
The A-type lamins have been observed to colocalize with RNA splicing factors in speckles within the nucleus, in addition to their typical distribution at the nuclear periphery. To understand the functions of lamin speckles, the effects of transcriptional inhibitors known to modify RNA splicing factor compartments (SFCs) were examined. Treatment of HeLa cells with alpha-amanitin or 5,6-dichlorob...
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The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1.
CA150 represses RNA polymerase II (RNAPII) transcription by inhibiting the elongation of transcripts. The FF repeat domains of CA150 bind directly to the phosphorylated carboxyl-terminal domain of the largest subunit of RNAPII. We determined that this interaction is required for efficient CA150-mediated repression of transcription from the alpha(4)-integrin promoter. Additional functional deter...
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چکیده ندارد.
Colocalization of intranuclear lamin foci with RNA splicing factors.
The lamins form a fibrous network underlying the inner nuclear membrane termed the nuclear lamina. In order to gain insights into the role of lamins in nuclear organization, we have characterized a monoclonal antibody (LA-2H10) raised against recombinant rat lamin A that labels nuclei in a speckled pattern in all cells of unsynchronized populations of HeLa and rat F-111 fibroblast cells, unlike...
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ژورنال
عنوان ژورنال: Cells
سال: 2021
ISSN: 2073-4409
DOI: 10.3390/cells10020297